Stimulation of stellate cells by injured acinar cells: A model of acute
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چکیده
1 pancreatitis induced by alcohol and fat (VLDL) 2 3 Siech M, Zhou ZF, Zhou S, Bair B, Alt A, Hamm S, Gross H, Mayer J, Beger 4 HG, Tian X, Kornmann M, Bachem MG 5 6 M Siech, ZF Zhou and S Zhou made equal contributions to this study and should be 7 considered first authors. 8 9 10 Department of General and Vascular Surgery, Ostalb-Klinikum Aalen 11 Departments of General and Transplantation Surgery, 12 Clinical Chemistry and 13 Legal Medicine, University of Ulm, Germany 14 and Department of General Surgery, The First Hospital of Peking University, China 15 16 Corresponding Author: 17 Marco Siech, MD 18 Department of General and Vascular Surgery 19 Ostalb-Klinikum Aalen, Teaching Hospital of University Hospital Ulm 20 Kaelblesrain 1 21 73430 Aalen, Germany 22 phone: +49-7361-55-1101 23 fax: +49-7361-55-1103 24 e-mail: [email protected] 25 26 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (October 1, 2009). doi:10.1152/ajpgi.90468.2008
منابع مشابه
Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL).
Mechanisms leading to acute pancreatitis after a fat-enriched meal combined with excess alcohol are incompletely understood. We have studied the effects of alcohol and fat (VLDL) on pancreatic acinar cell (PAC) function, oxidative stress, and repair mechanisms by pancreatic stellate cells (PSC) leading to fibrogenesis. To do so, PAC (rat) were isolated and cultured up to 24 h. Ethanol and/or VL...
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